Coinfection of typhoid fever and hepatitis B: a case report
DOI:
https://doi.org/10.24843/BAJ.2022.v05.i02.p02Keywords:
ACUTE hepatitis b, coinfection, thypoid feverAbstract
Background: Enteric fever (or more commonly known as typhoid fever) is an infectious disease characterized by systemic manifestations such as fever with a step-ladder pattern and abdominal pain. This disease is mainly caused by gram-negative bacteria Salmonella enterica serovar Typhi (S. typhi) and other Salmonella enterica serovars such as S. paratyphi A, S. paratyphi B and S. paratyphi C. Although there have been great advances in public health and hygiene in developing countries, enteric fever is still endemic in some of these countries with the case fatality rate of enteric fever reaching 2.49%. This study aims to further discuss the coinfection of typhoid fever with acute hepatitis B.
Case: A 40-year-old female patient who presented with the chief complaint of fever at night, nausea, vomiting and abdominal pain. Widal serological examination showed an increase in antibody titers of S. typhi and paratyphi. The results of laboratory tests showed increased levels of SGPT and SGOT. Follow-up immunoserology examination for HBsAg showed a reactive result. During hospitalization, the patient was given antibiotik therapy for typhoid infection and supportive therapy for acute hepatitis B. The occurrence of worsening symptoms, complications and manifestations of hepatitis (such as jaundice) was not observed in this patient.
Conclusion: It can be concluded that the manifestation of viral hepatitis coinfection in enteric fever varies from asymptomatic to fulminant hepatitis. The therapeutic strategy for co-infection of typhoid fever with viral hepatitis follows the therapeutic guidelines for each disease in addition to close monitoring of liver function.
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