Characteristics of α-Tocopherol Microemulsion in the Mixed Comparison of Three Nonionic Surfactants and Stiring Time

Abstract

Microemulsions have thermodynamics and stable kinetics as carriers of α-tocopherol compounds. This study  aimed to know the effect of mixtures ratio of three nonionic surfactants and stiring time on the characteristics  of α-tocopherol microemulsion, as well as to obtain the best stiring time and mixture ratio of three nonionic  surfactants to produce α-tocopherol microemulsion. This experiment used a randomized block design with two  factors. The first factor is the ratio of a mixture of three nonionic surfactants with Hydrophilic-Lipophilic  Balance (HLB) 14.5. The second factor is stirring time. Data were analyzed using analysis of variance and  continued with BNJ test. Test the effectiveness index to determine the best treatment. The results showed that  the comparison of three surfactant mixtures, stirring duration and interaction between treatments significantly  affected the characteristics of α-tocopherol microemulsion. Comparison of the mixture of three surfactants  Tween 80: Span 80: Tween 20 (v / v%) HLB 14.5 consisting of F2 (89,5 : 5,5 : 5) and 4 minutes stirring time  is the best treatment for the characteristics of α-Tocopherol microemulsion. The best treatment has the  characteristics of α-tocopherol microemulsions namely transparent appearance, stable to centrifugation  (4500 rpm), pH (4.5; 5.5 and 6.5) and dilution (1: 9, 1:49 and 1:99) with Turbidity index values are below 1  percent. Microemulsion turbidity index values before and after centrifugation were 0.19 percent and  microemulsion turbidity at pH 4.5 and 1: 9 dilution were 0.11 percent.