The Effect Of Variations Of Additional Glutaraldehyd And Glycerol On Characteristics Of Chitosan Hydrogel

Abstract

This study aims to determine the addition of glutaraldehyde as a crosslinking agent and glycerol as a  plasticizer to produce chitosan hydrogel with the best characteristics. This study used a factorial  Randomized Block Design with three treatment factors: the addition of glutaraldehyde (1gr, 2gr, and  3gr w/w) and the addition of glycerol (1gr, 2gr, and 3gr w/w). The variables observed were thickness,  adsorption, tensile strength, and elongation at break. The results showed that added glutaraldehyde and  glycerol significantly affected thickness, adsorption, tensile strength, and elongation of chitosan  hydrogel. Based on the result, the best characteristics of the chitosan-glutaraldehyde-glycerol hydrogel  are shown with the addition of 3 gr glutaraldehyde and 1 gr glycerol, which as value of 0.288±0.005  thickness, 1403.13±200.51 adsorption, 1.49±0.03 tensile strength, 26,64±0.21 elongation at break.